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Aplasia of the heart (acardius) is observed only with twin congenital malformations.
Aplasia of one of the paired organs usually causes vicarious hypertrophy of the other. Aplasia of one endocrine gland can cause hypo- or hypertrophy of furosemide glands. There may be aplasia of only part of an organ, for example, the olfactory brain (arynencephaly), the corpus callosum, etc. Focal tissue aplasia can be observed in the skin, most often on the scalp, where a defect is found at the birth of a baby, usually not exceeding 5 cm across. Skin aplasia can be combined with aplasia of deeper tissue, for example, in various forms of dysraphia (non-closure of embryonic fissures).